COMPOSTO DE GRIGNARD PDF

5 jul. 1- Dados os compostos de Grignard abaixo, forneça a nomenclatura de cada um deles: a) H3C — CH2— CH2— CH2— MgCl Cloreto de butil-. Keywords: allylic oxidation, selenium dioxide, homoallylic alcohols, Grignard adsorvido em SiO2, propicia uma rota conveniente para tais compostos. O primeiro estudo sistemático sobre os compostos organoestânicos (OTs, .. tetrassubstituído via reação de “Grignard” (brometo ou cloreto de etil, butil ou.

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The same procedure employed for the allylic compowto of 1 was used; compound 8 2. The same procedure as employed for the oxidation of 1 was used, starting with 7 3. After 30 min, geranyl bromide 2.

Preparation of aromatic geraniol analogues via a Cu(I)-mediated Grignard coupling

The solvent was removed under reduced pressure and the residue was diluted with ether 50 mL and water 30 mL and extracted with ether 2×50 mL.

After allowing the reaction mixture to reach ambient temperature, CuI was added followed by the addition of allylic alcohol 2. Scheme 2 shows the first attempt.

Se on Demand Journal. Kascheres on occasion of his 60 th birthday.

Difunctional allylic terpenes are important synthetic building grognard. Conclusion In brief, we optimized a selective oxidation of allylic methyl groups in geraniol derivatives over a solid support to the corresponding trans- ab -unsaturated alcohols and aldehydes, using selenium dioxide and t -butylhydroperoxide adsorbed on silica gel as oxidants. Alkylation of sodium salts, however, invariably leads to complex mixtures containing both ring and oxygen substituted products.

A suspension of selenium oxide 0. A wide variety of phenolic natural products contain isoprenoid residues. In this work we reported a revision study on the history of OTs and the techniques developed for its assessment and control. Then BuLi in hexane 2. Also, an efficient synthesis of 2-geranylphenol derivatives via a Cu I coposto Grignard coupling of 2-lithiophenols and geranyl substrates was developed.

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Organoclorado

Some OTs are used as pesticides in crops, or as biocides in antifouling paints, applied in the ship hulls to avoid attachment and growth of tube worms, mussels and barnacles. The solvent was removed under vacuum and the residue was diluted in ether 50 mL and water 30 mLthen extracted with ether 2×30 mLdried over MgSO 4 and filtered, and then the solvent was removed under reduced pressure.

The chosen protecting groups clearly influence the oxidation process. Using lower molar quantities of SeO 2 should reduce selenium by-products, facilitating the purification of gtignard products.

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After the disappearance of the starting material, water 30 mL was added and the mixture was extracted with dichloromethane 2×30 mL. Preparation of aromatic geraniol analogues via a Cu I -mediated Grignard coupling. The organic layer was washed with two portions of brine then dried with anhydrous MgSO 4. fomposto

Fall30 Environmental contamination for organotin compounds. A new sequence was investigated with another substrate in an attempt to improve the yield of the desired phenol-alcohol 9 Scheme 4.

Geranyl bromide 4 was necessary in the next steps and grihnard preparation although it is commercially available was achieved after some attempts in order to optimize the conditions for getting high yield. The mixture was compossto at ambient temperature for 8 h and then diluted with 30 mL of ether. In a three necked round bottom flask, tert -butyldimethylsilyl 2-iodophenol ether 11 3. Also, we developed an efficient synthesis of 2-geranylphenol derivatives via a Cu I -mediated Grignard coomposto of 2-lithiophenols and geranyl substrates.

To a solution of 2-iodophenol 2. The ether phase was washed with water 30 mLthen with brine 2×30 mLdried over MgSO 4filtered and the solvent was removed under reduced pressure grighard rotatory evaporation. How to cite this article.

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Bromination of geraniol 15 with phosphorus tribromide 0. S Services on Demand Journal. This result was still not satisfactory so we tried a different approach. Economic Entomology79 Economic Entomology81 The same procedure as employed for the coupling of 11 and 12 was usedstarting with tert -butyldimethylsilyl 2-iodophenol ether 11 3.

After the temperature reached room temperature, CuI 1. However, “nontarget” organisms may be exposed, resulting in the poisoning of biological system, originating mutations and sentencing species vomposto extinction.

How to cite this grjgnard. Geraniol was purchased from Aldrich Chem. To a two-necked mL round bottom flask with 2-iodophenyl tetrahydropyranyl ether 6 3. The same procedure as employed for allylic oxidation of 1 was used ; compound 13 3.

Em Organotin Compounds ; Sawyer, A. The mixture was stirred for 48 h. After stirring for 15 min at room temperature, cold pentane 25 compostp was added, and the organic layer was washed with cold water, extracted with pentane 2×25 mL and then washed with brine. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

The reaction was cooled, a saturated solution of NH 4 Cl was added, the solutions was extracted with ether 3×50 mLdried over MgSO 4filtered and the solvent was removed under reduced pressure by coomposto evaporation.

February 4, Published on the web: The Sharpless conditions for oxidation of geranyl acetate employs 0. Then a solution of 2 E – grignrad tetrahydro-2 H pyranyl ether 12